NXPE4

Across TCGA patient cohorts, NXPE4 mutation is significantly associated with the RNA expression of many other genes, with 4,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPE4-associated genes across cancer lineages are TRAIP, ITGB1BP1, and HROB. Each is linked with NXPE4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NXPE4-to-partner and partner-to-NXPE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAIP grouped by NXPE4-low versus NXPE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE4→partner) and Y-score (partner→NXPE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAIP →	+0.592	+2.202	<.001	.001	3	4
UCEC	ITGB1BP1 →	+0.324	+2.716	.009	.003	3	4
SKCM	HROB →	+0.601	+2.739	<.001	.003	3	4
UCEC	AUNIP →	+0.693	+2.732	.001	.002	3	4
UCEC	SGO1 →	+0.699	+2.931	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.920	+2.673	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,059 associations by consensus.

TRAIP by NXPE4 expression — UCEC

Explore this box plot interactively →