NXPE4

Across TCGA patient cohorts, NXPE4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NXPE4-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and ERK2. Each is linked with NXPE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE4-to-partner and partner-to-NXPE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by NXPE4-low versus NXPE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE4→partner) and Y-score (partner→NXPE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.278	+1.906	.033	.016	3	2
UCEC	eIF4E →	+0.234	+3.335	.005	.005	3	1
UCEC	ERK2 →	+0.189	+3.321	.014	.009	3	1
UCEC	FoxM1 →	+0.225	+2.179	.031	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-2.807	.001	.003	3	1
UCEC	Ku80 →	+0.255	+1.498	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

p62 Lck ligand by NXPE4 expression — UCEC

Explore this box plot interactively →