NXPE4

Across TCGA cell cohorts, NXPE4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NXPE4-associated genes across cancer lineages are KLF18, CRYGC, and ODF4. Each is linked with NXPE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXPE4-to-partner and partner-to-NXPE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF18 grouped by NXPE4-low versus NXPE4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXPE4→partner) and Y-score (partner→NXPE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KLF18 →	+0.007	+4.108	<.001	.005	3	1
LUNG_SCLC	CRYGC →	+0.040	+4.643	<.001	.004	3	1
LUNG_SCLC	ODF4 →	+0.111	+4.523	<.001	.003	3	1
LUNG_SCLC	C5orf52 →	+0.052	+4.643	<.001	.004	3	1
LARGE_INTESTINE	CCDC70 →	+0.027	+2.921	.007	.005	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KLF18 by NXPE4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →