Q-omics provides the consensus-scored NLRP3 profile across patient tissues and cancer cell-line models. NLRP3 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, NLRP3 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, NLRP3 RNA expression shows 22,505 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight SKCM, KIRC, and LSCC as cancer lineages where NLRP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NLRP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NLRP3 survival associations across molecular data types. NLRP3 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NLRP3 RNA expression–survival associations across cancer types. High NLRP3 expression shows favorable associations in SKCM, KIRC, UCEC, LUAD, HNSC and THCA. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for NLRP3 RNA expression.
This table summarizes NLRP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for NLRP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NLRP3 shows lower tumor expression in BLCA, LUSC, UCEC and BRCA and higher tumor expression in KIRC and HNSC. The KIRC box plot shows higher NLRP3 RNA expression in tumor versus normal tissue (log2 FC = +1.292, t-test p < 0.001).
This table shows molecular features associated with NLRP3 in patient tissues and cancer cell lines. In patient samples, NLRP3 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, NLRP3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
