NLRP3

Across TCGA patient cohorts, NLRP3 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP3-associated genes across cancer lineages are FOXO3a, GAPDH, and ACVRL1. Each is linked with NLRP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP3-to-partner and partner-to-NLRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by NLRP3-low versus NLRP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP3→partner) and Y-score (partner→NLRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a →	-0.065	-0.881	.025	.025	3	4
COAD	GAPDH →	+0.428	+1.493	.019	.035	3	4
COAD	ACVRL1 →	-0.178	-2.309	.049	.033	3	4
COAD	FASN →	+0.388	+1.915	.006	.009	3	4
COAD	PCNA →	+0.230	+2.423	.010	.001	3	4
UCEC	ASNS →	+0.400	+2.070	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

FOXO3a by NLRP3 expression — SKCM

Explore this box plot interactively →