NLRP3

Across TCGA pan-cancer cohorts, NLRP3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NLRP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NLRP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NLRP3 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

KIRC, BLCA, and HNSC are the cancer types where NLRP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NLRP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.292	<.001	11	view →
BLCA	Male	All	−1.013	<.001	8	view →
HNSC	Female	III,IV	+0.886	<.001	7	view →
LUSC	Male	II,III,IV	−1.737	<.001	6	view →
UCEC	All	All	−0.916	<.001	6	view →
BRCA	All	II,III,IV	−0.566	<.001	6	view →
COAD	Female	All	−0.299	.028	4	view →
KIRP	All	All	+0.591	.002	3	view →
LUAD	All	All	−0.387	.025	2	view →
LIHC	Male	All	−0.315	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NLRP3–KIRC

Open the KIRC breakdown →