NLRP3

Across TCGA patient cohorts, NLRP3 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,505 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NLRP3-associated proteins across cancer lineages are MYO1F, ARHGAP45, and AIF1. Each is linked with NLRP3 in more than 9 cancer types. Because this analysis shows association rather than direction, both NLRP3-to-partner and partner-to-NLRP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NLRP3 versus MYO1F in GBM, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP3→partner) and Y-score (partner→NLRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1F →	+0.728	+1.070	<.001	<.001	3	10
GBM	ARHGAP45 →	+0.643	+0.859	<.001	<.001	3	10
GBM	AIF1 →	+0.976	+1.175	<.001	<.001	3	10
LSCC	RASAL3_S72 →	+0.656	+0.864	<.001	<.001	3	9
GBM	ARHGAP30 →	+0.705	+0.946	<.001	<.001	3	9
GBM	ARHGAP9 →	+0.575	+0.912	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,505 associations by consensus.

NLRP3 vs MYO1F — GBM

Explore this scatter interactively →