NLRP3

Across TCGA patient cohorts, NLRP3 mutation is significantly associated with the RNA expression of many other genes, with 7,050 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP3-associated genes across cancer lineages are DNAJC9, NUSAP1, and SKA1. Each is linked with NLRP3 in more than 5 cancer types. Because this analysis shows association rather than direction, both NLRP3-to-partner and partner-to-NLRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC9 grouped by NLRP3-low versus NLRP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP3→partner) and Y-score (partner→NLRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJC9 →	+0.485	+1.960	<.001	<.001	3	6
LUAD	NUSAP1 →	+0.667	+1.514	<.001	<.001	3	6
UCEC	SKA1 →	+0.613	+1.974	<.001	<.001	3	6
UCEC	H2AZ1 →	+0.558	+2.184	<.001	<.001	3	6
UCEC	CHAF1A →	+0.703	+2.379	<.001	<.001	3	6
UCEC	RBM28 →	+0.271	+1.656	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,050 associations by consensus.

DNAJC9 by NLRP3 expression — UCEC

Explore this box plot interactively →