NLRP3

Across TCGA cell cohorts, NLRP3 mutation is significantly associated with the RNA expression of many other genes, with 1,335 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP3-associated genes across cancer lineages are H2BC9, LYZL2, and RIPK2. Each is linked with NLRP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLRP3-to-partner and partner-to-NLRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC9 grouped by NLRP3-low versus NLRP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP3→partner) and Y-score (partner→NLRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2BC9 →	-0.638	-2.459	.002	.006	3	3
STOMACH	LYZL2 →	+0.062	+3.432	<.001	.008	3	2
LUNG_NSCLC_LUAD	RIPK2 →	+0.590	+1.714	<.001	.005	3	2
LUNG_NSCLC_LUAD	NSUN4 →	+0.365	+2.513	.002	.004	3	2
LUNG_NSCLC_LUAD	DDX54 →	+0.346	+3.144	.005	.007	3	2
LARGE_INTESTINE	PDCD2L →	+0.486	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,335 associations by consensus.

H2BC9 by NLRP3 expression — LARGE_INTESTINE

Explore this box plot interactively →