NLRP3

Across TCGA cell cohorts, NLRP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,106 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NLRP3-associated GO terms across cancer lineages are Negative regulation of acute inflammatory response, Regulation of hemostasis, and Microvillus assembly. Each is linked with NLRP3 in more than 9 cancer types. Because this analysis shows association rather than direction, both NLRP3-to-partner and partner-to-NLRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of acute inflammatory response grouped by NLRP3-low versus NLRP3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP3→partner) and Y-score (partner→NLRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of acute inflammatory response →	-0.235	-1.060	<.001	<.001	3	9
SOFT_TISSUE	Regulation of hemostasis →	+0.162	+0.968	<.001	<.001	3	9
SOFT_TISSUE	Microvillus assembly →	+0.212	+0.993	<.001	<.001	3	9
SOFT_TISSUE	Regulation of blood coagulation →	+0.161	+0.968	<.001	<.001	3	9
SOFT_TISSUE	Regulation of coagulation →	+0.161	+0.893	<.001	<.001	3	9
BLOOD_Lymphoma	Urokinase plasminogen activator signaling pathway →	+0.834	+0.696	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,106 associations by consensus.

Negative regulation of acute inflammatory response by NLRP3 expression — SOFT_TISSUE

Explore this box plot interactively →