neuron derived neurotrophic factorGenealiases: C4orf31 · HH25 · NORD
Q-omics provides the consensus-scored NDNF profile across patient tissues and cancer cell-line models. NDNF expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, NDNF is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, NDNF RNA expression shows 21,536 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRP, KIRC, and LSCC as cancer lineages where NDNF shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NDNF — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NDNF survival associations across molecular data types. NDNF RNA expression shows survival associations in the most cancer types (25), followed by mutation status (8) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NDNF RNA expression–survival associations across cancer types. High NDNF expression shows unfavorable associations in KIRP, LUSC, THCA and OV, but favorable associations in LUAD and ESCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for NDNF RNA expression.
This table summarizes NDNF tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for NDNF. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NDNF shows lower tumor expression in KIRC, KIRP, LUAD, KICH, THCA and LUSC. The KIRC box plot shows higher NDNF RNA expression in normal versus tumor tissue (log2 FC = −3.442, t-test p < 0.001).
This table shows molecular features associated with NDNF in patient tissues and cancer cell lines. In patient samples, NDNF shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, NDNF RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Myeloma and SKIN.
