NDNF

Across TCGA pan-cancer cohorts, NDNF RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NDNF data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NDNF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NDNF expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

KIRP, LUSC, and THCA are the cancer types where NDNF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.578	0.856	<.001	63	view →
LUSC	OS	Tertile	All	0.305	0.491	<.001	50	view →
THCA	OS	Median	All	0.980	0.999	.004	36	view →
LUAD	DFS	Tertile	All	0.858	0.735	.002	30	view →
OV	OS	Quartile	III,IV	0.275	0.405	.009	24	view →
ESCA	DFS	Tertile	All	0.460	0.241	.006	22	view →
LAML	DFS	Tertile	All	0.525	0.289	.010	22	view →
SKCM	DFS	Quartile	All	0.532	0.724	.007	16	view →
STAD	DFS	Median	II,III,IV	0.427	0.608	.006	16	view →
DLBC	DFS	Median	II,III,IV	0.971	0.567	.016	14	view →
SCLC	DFS	Tertile	III,IV	0.715	0.323	.006	12	view →
CESC	DFS	Quartile	All	0.625	0.785	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NDNF–KIRP (OS)

Open the KIRP breakdown →