NDNF

Across TCGA cell cohorts, NDNF RNA expression is significantly associated with the go_rna of many other GO terms, with 1,141 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NDNF-associated GO terms across cancer lineages are Positive regulation of synaptic transmission, GABAergic, DNA replication-dependent chromatin disassembly, and Regulation of endoplasmic reticulum tubular network organization. Each is linked with NDNF in more than 5 cancer types. Because this analysis shows association rather than direction, both NDNF-to-partner and partner-to-NDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of synaptic transmission, GABAergic grouped by NDNF-low versus NDNF-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NDNF→partner) and Y-score (partner→NDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of synaptic transmission, GABAergic →	-0.180	-0.614	.001	.009	3	5
CNS	DNA replication-dependent chromatin disassembly →	+0.108	+0.999	<.001	.004	3	5
CNS	Regulation of endoplasmic reticulum tubular network organization →	+0.088	+0.944	.001	.009	2	6
LUNG_SCLC	G protein-coupled acetylcholine receptor signaling pathway →	-0.095	-0.823	.002	.001	3	5
CNS	COPII-coated vesicle budding →	+0.054	+0.911	.005	.007	2	5
LARGE_INTESTINE	Cellular respiration →	+0.037	+1.018	.006	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,141 associations by consensus.

Positive regulation of synaptic transmission, GABAergic by NDNF expression — KIDNEY

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