NDNF

Across TCGA patient cohorts, NDNF mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDNF-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and 14-3-3_beta. Each is linked with NDNF in more than 2 cancer types. Because this analysis shows association rather than direction, both NDNF-to-partner and partner-to-NDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NDNF-low versus NDNF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDNF→partner) and Y-score (partner→NDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.365	+2.117	<.001	.002	3	3
UCEC	Cyclin-B1 →	+0.685	+3.906	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.093	-2.295	.003	.005	3	2
UCEC	HER2_pY1248 →	-0.177	-2.115	.035	<.001	3	2
UCEC	ACVRL1 →	-0.108	-1.395	.012	.043	3	2
UCEC	JNK_pT183_Y185 →	-0.202	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

4E-BP1 by NDNF expression — UCEC

Explore this box plot interactively →