NDNF

Across TCGA pan-cancer cohorts, NDNF Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NDNF data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NDNF Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDNF expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

KIRC, UCEC, and CESC are the cancer types where NDNF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.180	0.796	.001	30	view →
UCEC	DFS	Median	All	0.977	0.825	.007	18	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.491	0.690	.014	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.080	0.427	.019	6	view →
BLCA	OS	Median	All	0.239	0.618	.047	6	view →
HNSC	DFS	Median	All	1.000	0.596	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NDNF–KIRC (DFS)

Open the KIRC breakdown →