NDNF

Across TCGA cell cohorts, NDNF mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NDNF-associated genes across cancer lineages are Niraparib, LCL161, and 123829. Each is linked with NDNF in more than 1 cancer types. Because this analysis shows association rather than direction, both NDNF-to-partner and partner-to-NDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by NDNF-low versus NDNF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDNF→partner) and Y-score (partner→NDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.358	+2.646	.045	.047	3	1
LARGE_INTESTINE	LCL161 →	+0.430	+2.646	.007	.047	3	1
LARGE_INTESTINE	123829 →	+0.647	+2.649	.025	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.574	+2.646	.021	.047	3	1
LARGE_INTESTINE	Quizartinib →	+0.368	+2.652	.022	.045	3	1
LARGE_INTESTINE	IAP_5620 →	+0.368	+2.649	.046	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Niraparib by NDNF expression — LARGE_INTESTINE

Explore this box plot interactively →