MOB family member 4, phoceinGenealiases: 2C4D · CGI-95 · MOB1 · MOB3 · MOBKL3 · PHOCN
Q-omics provides the consensus-scored MOB4 profile across patient tissues and cancer cell-line models. MOB4 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MOB4 is differentially expressed in 9, with the highest sampling consensus in KICH. Additionally, MOB4 RNA expression shows 19,416 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight ACC, KICH, and UVM as cancer lineages where MOB4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MOB4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MOB4 survival associations across molecular data types. MOB4 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (3) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MOB4 RNA expression–survival associations across cancer types. High MOB4 expression shows unfavorable associations in ACC, KIRP, LIHC, UVM and HNSC, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MOB4 RNA expression.
This table summarizes MOB4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 2. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MOB4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MOB4 shows lower tumor expression in KICH, THCA and UCEC and higher tumor expression in LIHC, CHOL and PAAD. The KICH box plot shows higher MOB4 RNA expression in normal versus tumor tissue (log2 FC = −1.598, t-test p < 0.001).
This table shows molecular features associated with MOB4 in patient tissues and cancer cell lines. In patient samples, MOB4 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, MOB4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in SKIN and UPPER_AERODIGESTIVE_TRACT.
