MOB4

Across TCGA patient cohorts, MOB4 mutation is significantly associated with the RNA expression of many other genes, with 1,821 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB4-associated genes across cancer lineages are RNU6-1213P, RNU6-486P, and RNU6-361P. Each is linked with MOB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB4-to-partner and partner-to-MOB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by MOB4-low versus MOB4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB4→partner) and Y-score (partner→MOB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1213P →	+0.508	+7.930	<.001	.008	3	2
LUAD	RNU6-486P →	+0.342	+7.930	<.001	.008	3	1
LUAD	RNU6-361P →	+0.463	+7.930	<.001	.008	3	1
LUAD	TRMT112P1 →	+0.228	+7.930	<.001	.008	3	1
LUAD	H2AB3 →	+0.074	+7.930	<.001	.008	3	1
UCEC	AQP7P3 →	+0.040	+3.707	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,821 associations by consensus.

RNU6-1213P by MOB4 expression — LUAD

Explore this box plot interactively →