Q-omics provides the consensus-scored MMP21 profile across patient tissues and cancer cell-line models. MMP21 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, MMP21 is differentially expressed in 6, with the highest sampling consensus in KICH. Additionally, MMP21 RNA expression shows 17,530 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, KICH, and UVM as cancer lineages where MMP21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MMP21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MMP21 survival associations across molecular data types. MMP21 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MMP21 RNA expression–survival associations across cancer types. High MMP21 expression shows unfavorable associations in KIRP, KICH, LGG and THCA, but favorable associations in COAD and UCEC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for MMP21 RNA expression.
This table summarizes MMP21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for MMP21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MMP21 shows lower tumor expression in KICH, LUSC, THCA and STAD and higher tumor expression in CHOL and LIHC. The KICH box plot shows higher MMP21 RNA expression in normal versus tumor tissue (log2 FC = −0.251, t-test p < 0.001).
This table shows molecular features associated with MMP21 in patient tissues and cancer cell lines. In patient samples, MMP21 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, MMP21 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUSC and LARGE_INTESTINE.
