MMP21

Across TCGA cell cohorts, MMP21 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP21-associated GO terms across cancer lineages are mRNA transport, Regulation of chromatin organization, and Viral translational termination-reinitiation. Each is linked with MMP21 in more than 7 cancer types. Because this analysis shows association rather than direction, both MMP21-to-partner and partner-to-MMP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA transport grouped by MMP21-low versus MMP21-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP21→partner) and Y-score (partner→MMP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	mRNA transport →	+0.042	+0.030	.002	<.001	3	8
LARGE_INTESTINE	Regulation of chromatin organization →	+0.035	+0.026	.006	.003	3	8
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.064	+0.051	<.001	<.001	3	7
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.166	+0.039	.001	.004	3	7
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.183	+0.050	<.001	<.001	3	7
SOFT_TISSUE	tRNA transcription →	+0.061	+0.025	.004	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,201 associations by consensus.

mRNA transport by MMP21 expression — LARGE_INTESTINE

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