MMP21

Across TCGA pan-cancer cohorts, MMP21 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MMP21 data layer compared with 8 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MMP21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP21 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

KIRP, KICH, and LGG are the cancer types where MMP21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.369	0.683	<.001	51	view →
KICH	DFS	Tertile	II,III,IV	0.551	0.969	.002	46	view →
LGG	DFS	Median	All	0.665	0.798	<.001	36	view →
COAD	DFS	Tertile	II,III,IV	0.788	0.300	<.001	30	view →
UCEC	DFS	Quartile	All	0.945	0.853	.004	26	view →
THCA	DFS	Median	II,III,IV	0.774	0.947	.009	26	view →
LIHC	OS	Median	II,III,IV	0.560	0.340	.005	25	view →
UCS	DFS	Quartile	III,IV	0.570	0.214	.011	20	view →
KIRC	DFS	Quartile	All	0.711	0.833	.006	20	view →
PRAD	OS	Median	All	0.976	1.000	.009	20	view →
MESO	DFS	Median	All	0.276	0.575	.014	15	view →
SCLC	DFS	Tertile	IV	0.174	0.651	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MMP21–KIRP (DFS)

Open the KIRP breakdown →