MMP21

Across TCGA pan-cancer cohorts, MMP21 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MMP21 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MMP21 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMP21 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCS, and CESC are the cancer types where MMP21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.160	0.712	<.001	45	view →
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
CESC	OS	Median	All	0.203	0.798	.001	18	view →
LIHC	OS	Median	II,III,IV	0.242	0.721	<.001	16	view →
BLCA	OS	Median	III,IV	0.205	0.686	<.001	12	view →
COAD	OS	Median	II,III,IV	0.001	0.860	<.001	9	view →
UCEC	OS	Median	II,III,IV	1.000	0.465	.032	4	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MMP21–HNSC (DFS)

Open the HNSC breakdown →