MMP21

Across TCGA patient cohorts, MMP21 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP21-associated genes across cancer lineages are Di-Ras3, 14-3-3_beta, and ERK2. Each is linked with MMP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP21-to-partner and partner-to-MMP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by MMP21-low versus MMP21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP21→partner) and Y-score (partner→MMP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.142	-3.308	.012	.009	3	2
UCEC	14-3-3_beta →	-0.094	-3.143	.014	.018	3	1
UCEC	ERK2 →	+0.197	+3.321	.007	.009	3	1
UCEC	GATA6 →	-0.132	-2.985	.033	.034	3	1
UCEC	NDRG1_pT346 →	-0.431	-2.321	.021	.033	3	1
UCEC	PCNA →	+0.221	+2.115	.007	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Di-Ras3 by MMP21 expression — UCEC

Explore this box plot interactively →