Q-omics provides the consensus-scored MAP2K3 profile across patient tissues and cancer cell-line models. MAP2K3 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, MAP2K3 is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, MAP2K3 protein abundance shows 24,556 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, KICH, and GBM as cancer lineages where MAP2K3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAP2K3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAP2K3 survival associations across molecular data types. MAP2K3 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (5) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAP2K3 RNA expression–survival associations across cancer types. High MAP2K3 expression shows unfavorable associations in UVM, ACC, LGG, COAD, OV and PAAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for MAP2K3 RNA expression.
This table summarizes MAP2K3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 7. The strongest signals are observed in KICH for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MAP2K3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAP2K3 shows lower tumor expression in KICH, BRCA, LUSC and KIRP and higher tumor expression in COAD and STAD. The KICH box plot shows higher MAP2K3 RNA expression in normal versus tumor tissue (log2 FC = −2.431, t-test p < 0.001).
This table shows molecular features associated with MAP2K3 in patient tissues and cancer cell lines. In patient samples, MAP2K3 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, MAP2K3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BONE.
