MAP2K3

Across TCGA patient cohorts, MAP2K3 mutation is significantly associated with the RNA expression of many other genes, with 1,843 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K3-associated genes across cancer lineages are NFILZ, EIF1AXP2, and RN7SKP44. Each is linked with MAP2K3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K3-to-partner and partner-to-MAP2K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFILZ grouped by MAP2K3-low versus MAP2K3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K3→partner) and Y-score (partner→MAP2K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NFILZ →	+0.079	+5.969	<.001	.002	3	2
SKCM	EIF1AXP2 →	+0.115	+4.208	<.001	.003	3	2
CESC	RN7SKP44 →	+0.195	+5.010	<.001	.009	3	2
BLCA	RNU6-887P →	+0.237	+6.048	<.001	<.001	3	2
BLCA	RNA5SP229 →	+0.497	+3.982	.002	.006	3	2
BLCA	F10-AS1 →	+0.515	+3.788	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,843 associations by consensus.

NFILZ by MAP2K3 expression — CESC

Explore this box plot interactively →