MAP2K3

Across TCGA cell cohorts, MAP2K3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,235 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAP2K3-associated GO terms across cancer lineages are Protein depolymerization, Cellular response to mechanical stimulus, and Cellular response to external stimulus. Each is linked with MAP2K3 in more than 8 cancer types. Because this analysis shows association rather than direction, both MAP2K3-to-partner and partner-to-MAP2K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by MAP2K3-low versus MAP2K3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K3→partner) and Y-score (partner→MAP2K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Protein depolymerization →	+0.094	+1.025	<.001	<.001	3	9
LUNG_SCLC	Cellular response to mechanical stimulus →	+0.087	+0.775	.002	.005	3	8
LUNG_SCLC	Cellular response to external stimulus →	+0.086	+0.775	.003	.005	3	8
SOFT_TISSUE	Regulation of microvillus length →	+0.184	+1.148	.004	<.001	2	9
BONE	Positive regulation of ruffle assembly →	+0.186	+1.492	<.001	<.001	3	8
BONE	Anterograde neuronal dense core vesicle transport →	+0.248	+1.297	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,235 associations by consensus.

Protein depolymerization by MAP2K3 expression — SOFT_TISSUE

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