MAP2K3

Across TCGA pan-cancer cohorts, MAP2K3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MAP2K3 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MAP2K3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP2K3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where MAP2K3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.916	1.000	.009	48	view →
CCRCC	DFS	Quartile	III,IV	1.000	0.552	.011	31	view →
LSCC	DFS	Median	II,III,IV	0.500	0.839	.003	28	view →
HNSC	OS	Quartile	IV	0.990	0.529	<.001	18	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	11	view →
UCEC	OS	Tertile	III,IV	1.000	0.345	.014	8	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MAP2K3–COAD (DFS)

Open the COAD breakdown →