MAP2K3

Across TCGA patient cohorts, MAP2K3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP2K3-associated genes across cancer lineages are GAPDH, Notch1, and PDCD4. Each is linked with MAP2K3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K3-to-partner and partner-to-MAP2K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MAP2K3-low versus MAP2K3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K3→partner) and Y-score (partner→MAP2K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.586	+2.999	.029	.035	3	1
UCEC	Notch1 →	+0.199	+2.321	.004	.035	3	1
UCEC	PDCD4 →	-0.771	-2.321	.001	.035	3	1
UCEC	Shc_pY317 →	-0.205	-2.321	.007	.035	3	1
UCEC	STAT3_pY705 →	-0.403	-2.321	.002	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.590	+2.827	.048	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAPDH by MAP2K3 expression — UCEC

Explore this box plot interactively →