MAP2K3

Across TCGA cell cohorts, MAP2K3 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP2K3-associated genes across cancer lineages are ELOA2, RSPH6A, and FBXL4. Each is linked with MAP2K3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP2K3-to-partner and partner-to-MAP2K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA2 grouped by MAP2K3-low versus MAP2K3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP2K3→partner) and Y-score (partner→MAP2K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ELOA2 →	+0.035	+3.630	.003	.001	3	2
LARGE_INTESTINE	RSPH6A →	+0.137	+2.881	<.001	.002	3	1
LARGE_INTESTINE	FBXL4 →	+0.708	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PCCB →	+0.675	+3.295	<.001	.003	3	1
LARGE_INTESTINE	NFYB →	+0.516	+3.212	.001	.006	3	1
LARGE_INTESTINE	PDS5A →	+0.608	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

ELOA2 by MAP2K3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →