LDL receptor related protein 4Genealiases: CLSS · CMS17 · LRP-4 · LRP10 · MEGF7 · SOST2
Q-omics provides the consensus-scored LRP4 profile across patient tissues and cancer cell-line models. LRP4 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LRP4 is differentially expressed in 14, with the highest sampling consensus in THCA. Additionally, LRP4 RNA expression shows 18,568 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, THCA, and THYM as cancer lineages where LRP4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LRP4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LRP4 survival associations across molecular data types. LRP4 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LRP4 RNA expression–survival associations across cancer types. High LRP4 expression shows unfavorable associations in KICH and LIHC, but favorable associations in KIRC, LGG, THCA and ACC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LRP4 RNA expression.
This table summarizes LRP4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 1. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for LRP4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LRP4 shows lower tumor expression in BRCA and higher tumor expression in THCA, KIRC, UCEC, KIRP and BLCA. The THCA box plot shows higher LRP4 RNA expression in tumor versus normal tissue (log2 FC = +3.908, t-test p < 0.001).
This table shows molecular features associated with LRP4 in patient tissues and cancer cell lines. In patient samples, LRP4 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, LRP4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BONE.
