LRP4

Across TCGA pan-cancer cohorts, LRP4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRP4 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LRP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRP4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LUAD, LSCC, and GBM are the cancer types where LRP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.852	0.982	.010	29	view →
LSCC	DFS	Median	III,IV	1.000	0.389	<.001	20	view →
GBM	OS	Quartile	All	0.553	0.285	.031	5	view →
HNSC	DFS	Tertile	II,III,IV	0.776	0.523	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRP4–LUAD (DFS)

Open the LUAD breakdown →