LRP4

Across TCGA pan-cancer cohorts, LRP4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LRP4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LRP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRP4 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

THCA, KIRC, and UCEC are the cancer types where LRP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	+3.908	<.001	11	view →
KIRC	Male	All	+0.937	<.001	11	view →
UCEC	All	All	+2.177	<.001	6	view →
KIRP	All	II,III,IV	+1.257	.010	6	view →
BLCA	Male	III,IV	+1.222	.008	6	view →
BRCA	All	III,IV	−1.193	<.001	6	view →
LIHC	All	II,III,IV	+0.777	<.001	6	view →
LUAD	Female	II,III,IV	−1.247	<.001	5	view →
LUSC	Male	All	+1.100	<.001	3	view →
COAD	All	All	+0.772	.016	3	view →
PAAD	Male	All	+1.400	.029	2	view →
STAD	Female	All	−1.270	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LRP4–THCA

Open the THCA breakdown →