LRP4

Across TCGA cell cohorts, LRP4 mutation is significantly associated with the RNA expression of many other genes, with 1,577 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP4-associated genes across cancer lineages are SLC4A1, TTC33, and BBS7. Each is linked with LRP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP4-to-partner and partner-to-LRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC4A1 grouped by LRP4-low versus LRP4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP4→partner) and Y-score (partner→LRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC4A1 →	+0.172	+2.881	<.001	.009	3	3
LARGE_INTESTINE	TTC33 →	+0.682	+3.628	<.001	<.001	3	3
LARGE_INTESTINE	BBS7 →	+0.746	+3.628	<.001	<.001	3	3
LARGE_INTESTINE	RAP1GDS1 →	+0.513	+3.628	.004	<.001	3	3
BLOOD_Leukemia	SGCB →	+1.460	+3.199	<.001	.007	3	3
SOFT_TISSUE	LALBA →	+1.528	+4.882	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,577 associations by consensus.

SLC4A1 by LRP4 expression — CNS

Explore this box plot interactively →