LRP4

Across TCGA patient cohorts, LRP4 mutation is significantly associated with the RNA expression of many other genes, with 5,806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP4-associated genes across cancer lineages are KIF23, KNL1, and CKAP2L. Each is linked with LRP4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRP4-to-partner and partner-to-LRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF23 grouped by LRP4-low versus LRP4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP4→partner) and Y-score (partner→LRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF23 →	+0.651	+2.718	.005	.003	3	5
COAD	KNL1 →	+0.486	+1.920	.004	.009	3	5
LUAD	CKAP2L →	+0.832	+2.234	<.001	.005	3	5
COAD	STIL →	+0.428	+2.428	.006	.002	3	5
UCEC	CDCA2 →	+0.767	+1.847	<.001	<.001	3	5
COAD	NDC80 →	+0.626	+3.713	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,806 associations by consensus.

KIF23 by LRP4 expression — LUAD

Explore this box plot interactively →