LRP4

Across TCGA patient cohorts, LRP4 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LRP4-associated genes across cancer lineages are LKB1, Bak, and Bid. Each is linked with LRP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRP4-to-partner and partner-to-LRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by LRP4-low versus LRP4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP4→partner) and Y-score (partner→LRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LKB1 →	+0.115	+2.000	.008	.009	3	4
UCEC	Bak →	+0.199	+1.459	.006	.011	3	4
LUAD	Bid →	+0.155	+2.334	<.001	.018	3	4
COAD	RAD51 →	+0.147	+2.230	.014	.006	3	4
STAD	mTOR →	-0.279	-3.169	.010	.018	3	3
COAD	ATM →	-0.589	-1.691	<.001	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

LKB1 by LRP4 expression — LUAD

Explore this box plot interactively →