La ribonucleoprotein 1, translational regulatorGenealiases: LARP · Lar1 · Lhp1
Q-omics provides the consensus-scored LARP1 profile across patient tissues and cancer cell-line models. LARP1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, LARP1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, LARP1 protein abundance shows 21,366 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight HNSC, COAD, and BRCA as cancer lineages where LARP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LARP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LARP1 survival associations across molecular data types. LARP1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (5) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LARP1 RNA expression–survival associations across cancer types. High LARP1 expression shows unfavorable associations in HNSC, KICH, UVM, LUAD and LIHC, but favorable associations in KIRC. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for LARP1 RNA expression.
This table summarizes LARP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 5. The strongest signals are observed in COAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for LARP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LARP1 shows higher tumor expression in COAD, KIRC, HNSC, LIHC, STAD and LUAD. The COAD box plot shows higher LARP1 RNA expression in tumor versus normal tissue (log2 FC = +0.865, t-test p < 0.001).
This table shows molecular features associated with LARP1 in patient tissues and cancer cell lines. In patient samples, LARP1 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, LARP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
