LARP1

Across TCGA pan-cancer cohorts, LARP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LARP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LARP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LARP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where LARP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LARP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.865	<.001	12	view →
KIRC	Female	All	+0.626	<.001	11	view →
HNSC	Male	All	+0.738	<.001	10	view →
LIHC	Female	II,III,IV	+1.582	<.001	9	view →
STAD	Male	II,III,IV	+1.167	<.001	9	view →
LUAD	All	III,IV	+0.957	<.001	9	view →
BLCA	All	III,IV	+0.597	<.001	9	view →
LUSC	Male	II,III,IV	+0.876	<.001	8	view →
BRCA	All	III,IV	+0.557	<.001	6	view →
CHOL	All	All	+2.246	<.001	5	view →
THCA	All	All	−0.272	.008	5	view →
READ	All	III,IV	+1.404	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LARP1–COAD

Open the COAD breakdown →