LARP1

Across TCGA cell cohorts, LARP1 mutation is significantly associated with the RNA expression of many other genes, with 1,360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARP1-associated genes across cancer lineages are REG3G, KSR2, and CCDC59. Each is linked with LARP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARP1-to-partner and partner-to-LARP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by LARP1-low versus LARP1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP1→partner) and Y-score (partner→LARP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	REG3G →	+1.035	+3.632	<.001	.009	3	2
LARGE_INTESTINE	KSR2 →	+0.478	+2.743	<.001	.001	3	2
LARGE_INTESTINE	CCDC59 →	+0.424	+2.043	.002	.008	3	2
LARGE_INTESTINE	NOB1 →	+0.546	+3.362	.001	.002	3	2
LARGE_INTESTINE	RFX5 →	+0.787	+3.321	<.001	.003	3	2
LARGE_INTESTINE	TIFA →	+0.833	+2.043	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,360 associations by consensus.

REG3G by LARP1 expression — STOMACH

Explore this box plot interactively →