LARP1

Across TCGA patient cohorts, LARP1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP1-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and mTOR_pS2448. Each is linked with LARP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARP1-to-partner and partner-to-LARP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LARP1-low versus LARP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP1→partner) and Y-score (partner→LARP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.575	+1.827	.001	.002	3	3
UCEC	INPP4B →	-0.196	-2.169	.042	.002	3	2
UCEC	mTOR_pS2448 →	-0.166	-2.308	<.001	<.001	3	2
UCEC	Notch1 →	+0.127	+1.375	.002	.020	3	2
UCEC	PCNA →	+0.247	+2.321	<.001	<.001	3	2
UCEC	PKC-b-II_pS660 →	-0.241	-1.184	.003	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caspase-7-cleavedD198 by LARP1 expression — UCEC

Explore this box plot interactively →