kelch like family member 31Genealiases: BKLHD6 · KBTBD1 · KLHL · bA345L23.2
Q-omics provides the consensus-scored KLHL31 profile across patient tissues and cancer cell-line models. KLHL31 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, KLHL31 is differentially expressed in 13, with the highest sampling consensus in COAD. Additionally, KLHL31 RNA expression shows 18,289 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LIHC, COAD, and THYM as cancer lineages where KLHL31 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KLHL31 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KLHL31 survival associations across molecular data types. KLHL31 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (8) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KLHL31 RNA expression–survival associations across cancer types. High KLHL31 expression shows unfavorable associations in LIHC, HNSC, LAML, COAD and LUAD, but favorable associations in ACC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for KLHL31 RNA expression.
This table summarizes KLHL31 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for KLHL31. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KLHL31 shows lower tumor expression in BRCA and HNSC and higher tumor expression in COAD, KIRC, KIRP and LIHC. The COAD box plot shows higher KLHL31 RNA expression in tumor versus normal tissue (log2 FC = +0.694, t-test p < 0.001).
This table shows molecular features associated with KLHL31 in patient tissues and cancer cell lines. In patient samples, KLHL31 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, KLHL31 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Leukemia.
