KLHL31

Across TCGA patient cohorts, KLHL31 protein abundance is significantly associated with the RNA expression of many other genes, with 3,273 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLHL31-associated genes across cancer lineages are MYLK2, PAK5, and WFDC2. Each is linked with KLHL31 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL31-to-partner and partner-to-KLHL31 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL31 versus MYLK2 in HNSC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL31→partner) and Y-score (partner→KLHL31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYLK2 →	+1.377	+0.649	<.001	<.001	3	1
HNSC	PAK5 →	-0.820	-0.557	.006	.008	3	1
HNSC	WFDC2 →	-1.734	-0.535	<.001	<.001	3	1
HNSC	TNNC2 →	+2.691	+0.677	.003	.001	3	1
HNSC	ATP1B4 →	+1.387	+0.493	<.001	.001	3	1
HNSC	HHATL →	+1.022	+0.453	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,273 associations by consensus.

KLHL31 vs MYLK2 — HNSC

Explore this scatter interactively →