KLHL31

Across TCGA pan-cancer cohorts, KLHL31 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KLHL31’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KLHL31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL31 is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where KLHL31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.694	<.001	11	view →
KIRC	Male	All	+0.487	<.001	11	view →
KIRP	Male	II,III,IV	+0.560	<.001	9	view →
LIHC	All	II,III,IV	+0.382	<.001	9	view →
BRCA	All	III,IV	−2.608	<.001	8	view →
HNSC	Male	All	−1.066	.007	6	view →
LUSC	All	All	+0.357	<.001	4	view →
STAD	All	All	+0.293	.003	4	view →
CHOL	All	All	+0.672	.003	2	view →
READ	All	All	+0.554	.003	2	view →
LUAD	Male	III,IV	+0.391	.006	2	view →
ESCA	All	II,III,IV	+0.295	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KLHL31–COAD

Open the COAD breakdown →