KLHL31

Across TCGA patient cohorts, KLHL31 mutation is significantly associated with the RNA expression of many other genes, with 776 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL31-associated genes across cancer lineages are IGHD5-12, IGHVII-33-1, and RAB9BP1. Each is linked with KLHL31 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL31-to-partner and partner-to-KLHL31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-12 grouped by KLHL31-low versus KLHL31-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL31→partner) and Y-score (partner→KLHL31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	IGHD5-12 →	+1.647	+5.421	<.001	.005	3	3
BLCA	IGHVII-33-1 →	+0.277	+4.840	.001	.002	3	3
BLCA	RAB9BP1 →	+0.079	+4.899	<.001	.005	3	2
UCEC	CKS1BP6 →	+0.355	+1.697	.001	.006	3	2
LUAD	OR8B1P →	+0.078	+7.108	<.001	<.001	3	2
UCEC	RN7SL478P →	+0.183	+1.716	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

IGHD5-12 by KLHL31 expression — READ

Explore this box plot interactively →