KLHL31

Across TCGA patient cohorts, KLHL31 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL31-associated genes across cancer lineages are STAT3_pY705, c-Met_pY1235, and eIF4E. Each is linked with KLHL31 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL31-to-partner and partner-to-KLHL31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by KLHL31-low versus KLHL31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL31→partner) and Y-score (partner→KLHL31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.450	-1.874	<.001	.049	3	2
UCEC	c-Met_pY1235 →	+0.061	+1.594	.047	.042	3	2
UCEC	eIF4E →	+0.213	+3.183	.014	.009	3	1
UCEC	JNK2 →	+0.294	+3.469	<.001	.002	3	1
UCEC	MSH2 →	-0.244	-2.973	.010	.035	3	1
UCEC	Notch1 →	+0.139	+2.183	.017	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

STAT3_pY705 by KLHL31 expression — UCEC

Explore this box plot interactively →