KLHL31

Across TCGA cell cohorts, KLHL31 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL31-associated genes across cancer lineages are OR11H2, VN1R2, and PRAMEF7. Each is linked with KLHL31 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL31-to-partner and partner-to-KLHL31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H2 grouped by KLHL31-low versus KLHL31-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL31→partner) and Y-score (partner→KLHL31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR11H2 →	+0.030	+4.977	.004	.007	3	2
BLOOD_Lymphoma	VN1R2 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	PRAMEF7 →	+0.064	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	PRAMEF4 →	+0.132	+4.867	<.001	.009	3	1
BLOOD_Leukemia	MYMK →	+0.026	+4.507	<.001	.001	3	1
BLOOD_Leukemia	OR10R2 →	+1.353	+3.551	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR11H2 by KLHL31 expression — SKIN

Explore this box plot interactively →