Q-omics provides the consensus-scored VN1R2 profile across patient tissues and cancer cell-line models. VN1R2 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, VN1R2 is differentially expressed in 6, with the highest sampling consensus in KIRC. Additionally, VN1R2 RNA expression shows 8,213 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight COAD, KIRC, and THYM as cancer lineages where VN1R2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for VN1R2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes VN1R2 survival associations across molecular data types. VN1R2 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible VN1R2 RNA expression–survival associations across cancer types. High VN1R2 expression shows unfavorable associations in COAD, UCEC, LUAD and BRCA, but favorable associations in ACC and UVM. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for VN1R2 RNA expression.
This table summarizes VN1R2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for VN1R2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. VN1R2 shows lower tumor expression in KIRC, THCA, KICH, KIRP, BRCA and UCEC. The KIRC box plot shows higher VN1R2 RNA expression in normal versus tumor tissue (log2 FC = −0.045, t-test p < 0.001).
This table shows molecular features associated with VN1R2 in patient tissues and cancer cell lines. In patient samples, VN1R2 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, VN1R2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LUNG_SCLC.
