KLHL31

Across TCGA pan-cancer cohorts, KLHL31 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KLHL31 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHL31 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL31 expression acts as an unfavorable survival marker.

HNSC, COAD, and LUSC are the cancer types where KLHL31 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.098	0.768	<.001	30	view →
COAD	OS	Median	All	0.109	0.669	<.001	18	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	15	view →
LUAD	OS	Median	All	0.090	0.788	<.001	12	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KLHL31–HNSC (OS)

Open the HNSC breakdown →