kelch like family member 12Genealiases: C3IP1 · DKIR
Q-omics provides the consensus-scored KLHL12 profile across patient tissues and cancer cell-line models. KLHL12 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, KLHL12 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, KLHL12 protein abundance shows 31,538 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, HNSC, and GBM as cancer lineages where KLHL12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KLHL12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KLHL12 survival associations across molecular data types. KLHL12 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (7) and mass-spec protein abundance (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KLHL12 RNA expression–survival associations across cancer types. High KLHL12 expression shows unfavorable associations in ACC, UVM, KIRP, LIHC and HNSC, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for KLHL12 RNA expression.
This table summarizes KLHL12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for KLHL12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KLHL12 shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, LUAD, KIRP and BLCA. The HNSC box plot shows higher KLHL12 RNA expression in tumor versus normal tissue (log2 FC = +0.803, t-test p < 0.001).
This table shows molecular features associated with KLHL12 in patient tissues and cancer cell lines. In patient samples, KLHL12 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, KLHL12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUSC and UPPER_AERODIGESTIVE_TRACT.
