KLHL12

Across TCGA cell cohorts, KLHL12 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,299 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KLHL12-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, Establishment of protein localization to endoplasmic reticulum membrane, and mRNA 3'-end processing. Each is linked with KLHL12 in more than 14 cancer types. Because this analysis shows association rather than direction, both KLHL12-to-partner and partner-to-KLHL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by KLHL12-low versus KLHL12-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL12→partner) and Y-score (partner→KLHL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.129	+0.562	.001	<.001	3	15
SOFT_TISSUE	Establishment of protein localization to endoplasmic reticulum membrane →	+0.124	+0.915	<.001	<.001	3	14
SOFT_TISSUE	mRNA 3'-end processing →	+0.080	+0.700	.001	<.001	3	13
OESOPHAGUS	RNA 3'-end processing →	+0.075	+0.674	.002	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Heterochromatin formation →	+0.058	+0.846	<.001	<.001	3	12
LUNG_SCLC	Regulation of microtubule-based process →	+0.065	+0.560	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by KLHL12 expression — PANCREAS

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