KLHL12

Across TCGA cell cohorts, KLHL12 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL12-associated genes across cancer lineages are RFX4, KCNJ5, and NDUFB10. Each is linked with KLHL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL12-to-partner and partner-to-KLHL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFX4 grouped by KLHL12-low versus KLHL12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL12→partner) and Y-score (partner→KLHL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFX4 →	+0.041	+2.444	<.001	.008	3	1
LARGE_INTESTINE	KCNJ5 →	+0.702	+3.263	<.001	.008	3	1
LARGE_INTESTINE	NDUFB10 →	+0.629	+3.067	<.001	.009	3	1
LARGE_INTESTINE	C1orf162 →	+0.334	+3.215	<.001	.009	3	1
LARGE_INTESTINE	RIPPLY1 →	+0.479	+3.241	<.001	.007	3	1
LARGE_INTESTINE	DRAM2 →	+0.748	+3.160	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RFX4 by KLHL12 expression — LARGE_INTESTINE

Explore this box plot interactively →